One proposal for aiding that navigation is the formation of a patent pool. A survey of the crispr patent landscape shows the improvement of technology, a diversity of potential sectors of application, and a new geopolitical balance of forces in the field. Oct 11, 2016 analysis of the geographic scope of patent protection by top inventors. Crisprcas9 patent landscape report patent livescape. It revolves around the use of crispr, originally derived from a dnacutting system used by bacteria, in the more complex. In this regard, guide rnas grnasthe components of the crispr. Intellectual property ip ownership of geneediting technologies is diversified among aca. More than 1,700 patents have been filed by hundreds of different institutions, companies, and researchers. With so much at stake, its little surprise that crispr technology has been mired in intellectual property ip rights disputes from the getgo. Crispr patent ruling leaves license holders scrambling. Jun 27, 2016 as discussions and the hype surrounding crisprs clustered regularly interspaced short palindromic repeats potential applications increase, so do the legal and financial risks. Journal of industrial microbiology and biotechnology link to article, doi.
If the address matches an existing account you will receive an email with instructions to reset your password. Based on the patent portfolios of the key players, there appears to be a single frontrunner in each of the older technologies. This study focuses on the nature of patent and non patent literature ac1vity, trends, and players within the. Pdf worldwide crispr patent landscape shows strong. A surprise ruling last week reignited the highprofile patent fight over who invented a key application of the genome editor crispr. Crispr geneediting technology is advancing, but licensing is complex. Crispr s ip landscape while genentech benefited from a patent claim that was unambiguous, the crispr ip landscape is much more convoluted. Feb 21, 2017 the crispr patent decision last wednesday, and the resulting chaos on the biotech market, suggests that crispr patent licenses have real valueand real consequences.
A recent analysis performed by clarivate analytics consultant jack hopwood on crispr technology is a good case study in the utility of the landscaping process, says the firms ed white. Like the technology itself, the future of the crispr patent landscape. Most patent filers did not wait for a court ruling on the crispr. The analy1cs are designed to provide an understanding of the technical and scien1. The uspto has also granted patents directed to crispr. S u r v e y i n g t h e c r i s p r p a t e n t wa r. The commercialization of genomeediting technologies harvard.
Inventions that tweak crispr s various molecular components in an effort to optimize the technology shape the patent landscape. Around 100 new patent families on crispr are published each month. Why is the patent landscape different around the world. Jan 24, 2018 the patent landscape related to crispr cas9 technology is complex, constantly changing, with several main actors dominating the field. The complexity of the patent licensing landscape has considerable implications for companies seeking to commercialize crispr. The allowance grants the university additional crispr.
Listeners will gain an understanding of the current situation, which will aid them to make licensing decisions if and when they intend to commercialise. It is the essential source of information and ideas that make sense of a world in constant. Berkeley vs broad may 2012 jennifer doudna emanuelle charpentier crispr cas9 system for genomic editing in vitroprokaryotic data dec 2012 feng zhang crispr cas9 system for genomic editing in eukayrotes u. Topics biology crispr crispr cas9 genetics patents wired is where tomorrow is realized. Sep 30, 2017 inventions that tweak crisprs various molecular components in an effort to optimize the technology shape the patent landscape. Both dupont and wuhan university show very high recency and growth rate over the past 3 years. We offer products for the use of geneediting technology known as crispr. Following the publication of our recent technology landscape study on crispr cas9, maxval announces the latest advanced publication on the genome editing system, crispr, which has become an extremely important tool in medical research. Learn about the genome editing system, crispr, which has become an extremely important tool in medical research. Patent and trademark office declared an interference between certain crispr cas9 patent applications submitted by the university of california, the university of vienna, and emmanuelle charpentier and certain patents i. Cellectis for talens and dow agrosciences for meganucleases.
Crispr regions, and similarly narrow applications encompassing strain typing, phage resistance and uses in bacteria, the current crispr patent landscape appears enormously varied, both in terms of the patentees and applicants involved and the types of claims sought. The epo opposition division had revoked the patent for lack of novelty in view of. The existing players in the gene editing field appear to have adopted crispr in addition to the older technologies judging from the increase in the number of their crispr related patent filings and licensing deals. Sherkows policy forum crispr, surrogate licensing, and scientific discovery 17 february, p. In a highprofile patent battle between the university of california uc, berkeley and the broad institute, scientists are fighting for commercial claims to the foundational crispr. Epo decision in case t 84418 on the crispr gene editing. The emerging patent landscape of crisprcas gene editing technology. A new merck kgaa, darmstadt, germany partnership aims to simplify this path, accelerating research.
One of the inventors on that patent, molecular biologist jennifer doudna of the university of california in berkeley, likened the situation to licensing permission to someone who wants to use green tennis balls. Those include one hospital, five universities, and one researcher, namely. The crispr patent landscape of the future is uncertainuncertain due to the power of the technology, the sentiment of researchers and their institutions, and the quirks of patent. As for the past, the origins of the crispr patent landscape predate its use as a gene editing.
Is the patent system the way forward with the crisprcas 9. Nor is it clear how academic scientists and technology transfer offices will respond to the patent dispute. According to data gathered by the switzerlandbased consulting firm ipstudies, more than 12,000 crispr patent. The uspto has also granted patents directed to crispr cas9 to uc berkeley ucb, university of vienna and emmanuelle charpentier. Crispr clustered regularly interspaced short palindromic repeats allows scientists to edit genomes in living organisms at the cellular level by guiding a scissorlike protein to targeted sections of dna within a cell, and then prompting it to alter or edit the dna in some way. A decision on who owns the patent for crispr favors the broad. Crispr patent landscape sampleaugust 2017 20142017 table of contents 4 methodology overall trends of the crispr patent database temporal distribution of patent filings 2002 2017 temporal distribution of patent.
Maxvals crispr report is now available through patent livescape, an analysis and reporting service that provides clients with interactive reports which extract actionable and predictive information. The development of crispr depends, in part, on the patentspast, present, and futurecovering it. An interactive patent landscape report on crispr cas9. A decision on who owns the patent for crispr favors the. The broad institute of mit and harvard may lose a substantial number of european patent claims covering crispr cas9, but it has at least one trump card to play before we get to that stage, one european patent attorney has told lsipr. Pdf a survey of the crispr patent landscape shows the improvement of technology, a diversity of potential sectors of application, and a new.
Nih approved clinical trial for crisprmodified cells for cancer gene therapy. Crispr cas9 allows more precision, easeofuse, and is inexpensive when compared to other existing techniques such as zfn, talen and meganuclease for gene editing. These guidelines are focused on the use of patent information, i. Apr 25, 2017 the crispr ip landscape in europe is very murky. In the united states, broad has been allowed 20 patents for crispr cas9, as well as three for crispr cas12cpf1. The development of crispr depends, in part, on the patents past, present, and futurecovering it. The uncertainty around the patent landscape likely fueled the hestiation, he says but such uncertainty is not uncommon in. Crisprcas9 patent landscape report patent livescape maxval. Jan 08, 2018 if the address matches an existing account you will receive an email with instructions to reset your password. International patent landscape archives crispr collective. Last weeks granting of patent 10,266,850 follows a bitterlyfought, highprofile dispute between its owners the university of california, emmanuel charpentier and the university of.
The progress in biomedical research over the last four decades has been accompanied by. There may be a path through the crispr patent jungle, but there are many obstacles still in the way, say european. Crisprs ip landscape while genentech benefited from a patent claim that was unambiguous, the crispr ip landscape is much more convoluted. The ease and reliability of crispr threatens many future patents as being obvious.
Broad institute wins bitter battle over crispr patents. Broadmit gets the patent in eukaryotic cells, which is to say, plants and. Crispr clustered regularly interspaced short palindromic repeats allows scientists to edit genomes. The allowance grants the university additional crispr ip rights which include the single guide rnacas9 complex in both cellular and noncellular environments.
The patent landscape related to crispr cas9 technology is complex, constantly changing, with several main actors dominating the field. Though true clarity in the crispr patent landscape is years away, important developments are on the horizon in 2018. This shows the top 9 patent applicants by inven1on volume within the overall crispr landscape. The patent landscape related to crispr cas9 technology is complex, constantly changing, with several main actors dominating the field 21. The report crispr cas9 genome editing market and patent landscape report, by applications academic research tools, drug development, agriculture, human clinical therapeutics, and animal and disease model, by products editing tools, cell lines, animal models and plant breeding products, by technology drug compound and target screening, and agriculture and industrial use, by patent. In a highprofile patent battle between the university of california uc, berkeley and the broad institute, scientists are fighting for commercial claims to the foundational crispr ip.
Most work in the crispr field is being done in the u. The number of crispr cas9 inventions, as represented by patent families, by year of original priority filing for each patent family, together with a count of. At its heart, though, the landscape is a process a tool that is used by innovating companies. In this regard, guide rnas grnasthe components of the crispr system that lead the cas9 enzyme to precise locations within target dnacan be altered to home in on an infinite number of genes and to perform moreselective cuts.
Ucal granted wideranging crispr rights, but future patent. Landscape analysis of crisprcas9 an analysis of patent. In europe, the broad has been granted ten patents but is in danger of losing as many as eight of them, notes catherine coombes, a patent. Statement and background on crispr patent process broad. As crispr based innovations begin to move into clinical testing and the dispute over core patents continues worldwide, crispr cas9 gene editing has been under increased scrutiny in both commercial and academic sectors. A new merck partnership aims to simplify this path, accelerating research.
Technology landscape study on crispr cas9 2 executive summary although crispr was known to have an important role in bacterial immunity for over a decade, it is only in the last 5 years that it has garnered interest as a gene editing tool. The emerging patent landscape of crisprcas gene editing. In contrast to the past, the crispr landscape of the present is enormously varied, with more specific claims scattered among the hands of many. European patent office epo awarded the doudnacharpentier team a broad crispr cas9 patent ep patent no. Flux and uncertainty in the crispr patent landscape the. Navigating the crispr patent landscape and business impact. The patent landscape is a term we use freely, but it can mean different things to different people.
Life sciences patent attorneys might remember 2017 as the year they finally took notice of crispr. C learing a way through the crispr patent jungle is a difficult task. The 3yearold battle pits parties represented by the university of california uc against the broad institute in cambridge, massachusetts. This 45minute webinar will provide an up to date ana. Merck offers products for the use of geneediting technology known as crispr. As for the past, the origins of the crispr patent landscape predate its use as a gene editing technology. Crispr cas9 is a technology with the potential for an unimaginable impact on society. Allea permanent working group on intellectual property. Massachusetts general hospital, duke university, the broad institute joint harvard and mit entity, the university of california. Mar 04, 2020 the report crispr cas9 genome editing market and patent landscape report, by applications academic research tools, drug development, agriculture, human clinical therapeutics, and animal and disease model, by products editing tools, cell lines, animal models and plant breeding products, by technology drug compound and target screening, and agriculture and industrial use, by patent. Uc and the broad are not the only ones that have acquired crispr patents many other academic institutions and biotechnology companies are also in the crispr business. Fundamental pat ents covering crisprcas9 as a genomic. Those include one hospital, five universities, and one. By leveraging data sciences best practices, maxval has constructed an interactive report that melds different yet related data sources into a comprehensive landscape.
Oct 26, 2017 the crispr patent landscape elsewhere is also uncertain. The broad institute of mit and harvard may lose a substantial number of european patent claims covering crispr cas9, but it has at least one trump card to play before we get to that stage, one european patent attorney has told lsipr catherine coombes, patent director at hgf in the uk, said such an outcome would not create a clear ip landscape. Berkeley will get the patent for using the system called crispr cas9 in any living cell, from bacteria to blue whales. Patentrelated aspects of crisprcas technology allea. Fortytwo us patent applications involving crispr were filed in 2014. The protracted crispr patent fight took yet another turn when the united states patent and trademark office uspto issued a notice of allowance to uc berkeley last month. Like the technology itself, the future of the crispr patent landscape depends on researchers and their institutions. Crispr cas9 genome editing market patent landscape report.